Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel

Domains in macromolecular complexes are often considered structurally and functionally conserved while energetically coupled to each other. In the modular voltage-gated ion channels the central ion-conducting pore is surrounded by four voltage sensing domains (VSDs). Here, the energetic coupling is mediated by interactions between the S4-S5 linker, covalently linking the domains, and the proxim...

Psychiatric presentation of voltage-gated potassium channel antibody-associated encephalopathy. Case report.

Voltage-gated potassium channel antibody encephalopathy, a rare cause of limbic encephalopathy, typically presents with memory impairment and seizures. Psychiatric symptoms have not been emphasised in the literature. Here we describe a 58-year-old man who presented with panic attacks and psychogenic non-epileptic seizures and, later on, developed delusions and hallucinations and then confusion....

Voltage Gated Potassium Channel Antibody Encephalitis Associated with Hyperglycemia

In February 2013, a 65-year-old man with well-controlled hypertension and low testosterone presented to the hospital for evaluation of multiple, progressive, neurologic complaints. In 2012, he had begun to experience fragmented sleep, as well as intermittent episodes of drenching sweats, with hot flashes during the day and hypersalivation at night. In January 2013, he developed paroxysmal episo...

Motor Neuron Disease Associated with Voltage-Gated Potassium Channel Antibodies

Introduction: Antibodies to voltage-gated potassium channels have been implicated in causing a host of peripheral and central nervous system disorders. However, the presence of these antibodies has not been previously associated with motor neuropathy. We describe the first case of acquired motor neuron disease associated with voltage-gated potassium channel antibodies. Case Report: The patient ...

Voltage-gated potassium channel antibody-associated encephalitis with claustrum lesions.